Interleukin 17, Recombinant, Mouse (IL-17, IL17, Interleukin-17A, IL-17A, Cytotoxic T-lymphocyte-associated Antigen 8, CTLA-8, Il17a, Ctla8, Il17)

Size

£351.00

SKU:: 149694
Purity:: ≥98% (SDS-PAGE and HPLC). Endotoxin: ≤0.1ng/ug (1EU/ug).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder. Reconstitute with sterile dH2O to ≥0.1mg/ml.
Extra Details:: The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant mouse IL-17A is a 30kD disulfide-linked homodimer of two 133aa polypeptide chains. Source: Recombinant protein corresponding to mouse IL-17A, expressed in E.coli. Biological Activity: Measured by its ability to induce IL-6 production by NIH 3T3 cells. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice