TNFSF18, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, GITRL, hGITRL, TL6, UNQ149/PRO175, MGC138237)

Size

£341.00

SKU:: 149657
Purity:: ~98% (SDS-PAGE and HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder.
Extra Details:: AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177aa, including a 28aa cytoplasmic region, a 21aa transmembrane domain and a 128aa extracellular domain. Recombinant human soluble AITRL is a 14.3kD protein, containing 126aa corresponding to the extracellular domain of AITRL. Source: Recombinant protein corresponding to human TNFSF18, expressed in E.coli. Biological Activity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1-10ng/ml. Note: Results may vary with PBMC donors. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.