ZBTB7A (Zinc Finger and BTB Domain-containing Protein 7A, ZBTB7, Factor Binding IST Protein 1, FBI1, FBI-1, Factor That Binds to Inducer of Short Transcripts Protein 1, HIV-1 1st-binding Protein 1, Leukemia/lymphoma-related Factor, LRF, POZ and Krueppel Erythroid Myeloid Ontogenic Factor, POK Erythroid Myeloid Ontogenic Factor, Pokemon, TTF-I-interacting Peptide 21, TIP21, Zinc Finger Protein 857A, ZNF857A)

Size

£655.00

SKU:: 146787
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 16aa from near the N-terminus of human ZBTB7A.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells. Applications: Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Ovary Tissue Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice