TNFRSF14, NT (Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpes virus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-like 2, TR2, CD270, HVEA, HVEM, UNQ329/PRO509)

Size

£655.00

SKU:: 146080
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to 15aa from near the N-terminus of human TNFRSF14.
Format:: Supplied as a liquid in PBS, 0.02% sodium azide.
Extra Details:: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Applications: Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 1ug/ml Immunofluorescence: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse Thymus Tissue Lysate Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice