Activin A, Recombinant, Human/Mouse/Rat, aa311-426 (INHBA)

Size

£850.00

SKU:: 145698
Molecular Weight:: 15
Purity:: ≥97% (SDS-PAGE). Endotoxin: ≤0.10EU/ug (LAL).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in Acetonitrile, TFA. BSA free. Reconstitute with 100ul sterile PBS.
Extra Details:: Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A -beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha-beta A) and Inhibin B (alpha-beta B). Recombinant protein corresponding to aa311-426 from human Activin A GMP, CHO-derived. Molecular Weight: ~15kD Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice