SGC 0946 (1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea)

Size

£304.00

SKU:: 145692
Molecular Weight:: 618.57
Purity:: ~99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a white solid.
Extra Details:: Potent DOT1L methyltransferase inhibitor (KD = 0.06nm, IC50 = 0.3nm in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8nm respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. Sequence: C28H40BrN7O4 Solubility: DMSO (~100mM), Ethanol (~100mM) Molecular Weight: ~618.57 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

SGC 0946 (1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-­bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro­xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro­pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea)