PD 0332991 Isethionate (6-acetyl-8-cyclopentyl-5-methyl-2-[ [5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d] pyrimidin-7(8H)-one isethionate salt)

Size

£544.00

SKU:: 145686
Molecular Weight:: 573.66
Purity:: ~98% (HPLC)
Storage Conditions:: RT
Supplier:: United States Biological
CAS Number:: 827022-33-3
Format:: Supplied as a yellow solid.
Extra Details:: Potent Cdk4/6 inhibitor (IC50 values are 11 and 15nm for Cdk4 and Cdk6 respectively). Selective for Cdk4/6 over a panel of 34 additional protein kinases (IC50 values are > 10um). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant. Sequence: C24H29N7O2.C2H6O4S Solubility: DMSO (~10mM), H2O (~100mM) Molecular Weight: ~573.66 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.