145682
N,N-Dimethylsphingosine ((2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol)
Size
£382.00
- SKU:
- 145682
- Molecular Weight:
- 327.55
- Purity:
- ~98% (HPLC)
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 119567-63-4
- Format:
- Supplied as a clear oil.
- Extra Details:
- Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1beta and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism. Sequence: C20H41NO2 Solubility: DMSO (~30mM) Molecular Weight: ~327.55 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice