ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline )

Size

£382.00

SKU:: 145681
Molecular Weight:: 226.32
Purity:: ~99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 5465-86-1
Format:: Supplied as a off-white solid.
Extra Details:: Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Sequence: C15H18N2 Solubility: DMSO (~100mM), 1eq. HCl (~25mM) with gentle warming Molecular Weight: ~226.32 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.