KC7F2 (N,N'-(Dithiodi-2,1-ethanediyl)bis[2, 5-dichlorobenzenesulfonamide)

Size

£306.00

SKU:: 145680
Molecular Weight:: 570.38
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 927822-86-4
Format:: Supplied as a white solid.
Extra Details:: Inhibitor of HIF-1alpha. Thought to act via down-regulation of HIF-1alpha protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1alpha accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2. Sequence: C16H16Cl4N2O4S4 Solubility: DMSO (~100mM) Molecular Weight: ~570.38 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.