JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione)

Size

£395.00

SKU:: 145679
Molecular Weight:: 394.38
Purity:: ~97% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 442644-28-2
Format:: Supplied as a solid.
Extra Details:: Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Sequence: C21H18N2O6 Solubility: DMSO (~100mM) Molecular Weight: ~394.38 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2'-[1,3]dioxane­-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione)