Elacridar hydrochloride (GF 120918, P-gp inhibitor, (N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride)

Size

£471.00

SKU:: 145672
Molecular Weight:: 600.1
Purity:: ~98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 143851-98-3
Format:: Supplied as a yellow solid.
Extra Details:: P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. Sequence: C34H33N3O5.HCl Solubility: DMSO (~50mM) Molecular Weight: ~600.1 Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Elacridar hydrochloride (GF 120918, P-gp inhibitor, (N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-­2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-m­ethoxy-9-oxo-4-acridinecarboxamide hydrochloride)