145636
TNF alpha-induced Protein 3 (A20, TNFAIP3, OTUD7C, TNFA1P2)
Size
£761.00
- SKU:
- 145636
- Purity:
- Purified by Protein A affinity chromatography from hybridoma culture supernatant.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Lys91-Leu263 from human A20/TNFAIP3 expressed in E. coli.
- Clone:
- 775928
- Format:
- Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
- Extra Details:
- A20, also called TNF alphainduced protein 3 (TNFAIP3), is a cytoplasmic zinc finger protein that inhibits NF kappa B activity and tumor necrosis factormediated programmed cell death. The protein interacts with NAF1 and inhibits TNFinduced NF kappa Bdependent gene expression by interfering with RIP or TRAF2mediated transactivation signaling. A20 contains an Nterminal domain which has deubiquitinating enzyme activity and removes ubiquitin chains from receptorinteracting protein (RIP), thus mediating distinct regulatory effects in the downregulation of NF kappa B signaling. Applications: Suitable for use in ELISA and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry: 8-25ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice