145406
Caspr1 (Contactin-associated Protein-1, Neurexin-4, CNTNAP, CNTNAP1, p190)
Size
£876.00
- SKU:
- 145406
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Sheep
- Immunogen:
- Recombinant protein corresponding to aa20-1280 from human Caspr1, CHO-derived (UniProt # P78357).
- Format:
- Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
- Extra Details:
- CASPR1 (ContactinASsociated PRotein1; also Neurexin4 and p190) is a 180195kD member of the neurexin family of proteins. It is expressed on both axons and dendrites of neurons, and likely serves the critical function of directing the movement of low MW contactin, AMPA receptors, and Na+ plus K+ channels to appropriate sites on the cell membrane. This indicates participation in key processes such as myelination and excitatory neurotransmission. Mature human CASRP1 is a 1365 amino acid (aa) type I transmembrane protein. It contains a 1264aa extracellular region (aa201283) plus an 80aa cytoplasmic domain. The extracellular region is highly modular, possessing one discoidin (carbohydratebinding) domain (aa24158), four laminin Glike domains (aa203513, 813956 and 10881250), two EGFlike domains (aa540577 and 957996) and one fibrinogen Cterminal globular regions (aa576795). There is one potential alternative start site at Met507. Over aa201280, human CASPR1 shares 94% aa sequence identity with mouse CASPR1. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 515ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice