145300
Toll-like receptor 10 (h.TLR10)
Size
£620.00
- SKU:
- 145300
- Application:
- WB
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to a sequence at the N-terminal of human TLR10.
- Format:
- Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
- Extra Details:
- TLR10 (Toll-like receptor 10), is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al. (2005) determined that the TLR10 gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al. (2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM (TICAM2), or TRIF (TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined. UniProt Number: Q9BXR5 Gene ID: TLR10 Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice