Smad4 (DPC4) (JIP, DPC4, MADH4, MYHRS, MAD homolog 4, , MAD, mothers against decapentaplegic homolog 4 (Drosophila), SMAD, mothers against DPP homolog 4 (Drosophila), SMA- AND MAD-RELATED PROTEIN 4, DELETED IN PANCREATIC CARCINOMA 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4)

Size

£620.00

SKU:: 145197
Storage Conditions:: 4°C/-20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant human Smad4 (DPC4).
Clone:: IMD-89
Format:: Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
Extra Details:: SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. UniProt Number: Human(Q13485), Mouse(P97471), Rat(O70437) Gene ID: SMAD4 Applications: Suitable for use in Western Blot and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20˚C for one year. After reconstitution, store at 4˚C for one month. Can also be aliquoted and stored frozen at -20˚C for long term. Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.