145188
SLC6A1 (Solute carrier family 6 member 1)
Size
£620.00
- SKU:
- 145188
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to a sequence in the middle region of human SLC6A1, identical to the related rat and mouse sequences.
- Format:
- Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
- Extra Details:
- SLC6A1(Solute Carrier family 6 (Neurotransmitter transporter, Gaba), Member 1), also called GABATR or GABATHG, encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. The SLC6A1 gene contains 15 exons and is approximately 25 kb by Lam et al. And it is mapped on 3p25.3. Zomot et al. (2007) showed that introduction of a negatively charged amino acid at or near 1 of the 2 putative sodium binding sites of the GABA transporter GAT1 from rat brain (also calledSLC6A1) renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the SLC6A1 insertion promoter (2 copies of the sequence) had significantly greater promoter activity than the noninsertion (1 copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that the SLC6A1promoter genotype predicted SLC6A1 RNA expression and that overall SLC6A1 expression decreased with age. UniProt Number: P30531 Gene ID: SLC6A1 Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: paraffin Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice