Endostatin, Recombinant, Human (Collagen alpha-1(XVIII) Chain, COL18A1)

Size

£364.00

SKU:: 143314
Molecular Weight:: 20.2
Purity:: ≥98% (SDS-PAGE gel and HPLC analyses). Endotoxin: ≤1EU/ug
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder. No preservative added. Reconstitute with sterile PBS to 0.1-1mg/ml.
Extra Details:: Endostatin is a naturally occurring 20kD polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant protein corresponding to human Endostatin, a 20.2kD protein consisting 184aa residues, expressed in E. coli. Biological Activity: Measured by its ability to inhibit HUVEC migration. Amino Acid Sequence: MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.