137438
Gö6976 (ATP-competitive PKC Inhibitor Specific for Ca2+-dependent PKCalpha and PKCBeta1)
Size
£486.00
- SKU:
- 137438
- Molecular Weight:
- 378.43
- Purity:
- ≥99%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 136194-77-9
- Format:
- Supplied as a lyophilized powder.
- Extra Details:
- Gö6976 is an ATP-competitive PKC inhibitor specific for Ca2+-dependent PKCalpha (IC50= 2.3nM) and PKCBeta1 (IC50 = 6.2nM) isozymes (1). It is also a potent inhibitor of PKD (IC50= 20nM) (2). Researchers have demonstrated that Gö6976 blocks JNK activation (3-5) and inhibits PKCalpha-mediated, TPA-stimulated phosphorylation of CREB at Ser133 (6,7). Gö6976 is also an effective inhibitor of the tyrosine kinases Jak2 and FLT3 (8), as well as TrkA and TrkB (9). Synonyms: Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole CAS No: 136194-77-9 Molecular Formula: C₂₄H₁₈N₄O Solubility: 25mg/ml (DMSO). Usage: For a 1mM stock, reconstitute the 500ug in 1.32ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-10uM for 0.5-1 hr prior to treating with a stimulator or is used alone with varying treatment times lasting up to 24 hr. Soluble in DMSO at 25mg/ml; very poorly soluble in ethanol and water with maximum solubility in water at ~1-5uM. Purity: ≥99% Form: Supplied as a lyophilized powder. Storage and Stability: Store at -20°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice