SYK, Catalytic, Active, Recombinant, Human, GST-Tag (Tyrosine-protein Kinase SYK, Spleen Tyrosine Kinase)

Size

£912.00

SKU:: 137379
Molecular Weight:: 58
Purity:: Purified (~60%)
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 40mM Tris-HCl, pH 8, 110mM sodium chloride, 2.2mM potassium chloride, 4mM glutathione, 20% glycerol, 3mM DTT.
Extra Details:: Syk is a cytoplasmic 72kD non-receptor tyrosine kinase that is widely expressed in hematopoietic cells. The Syk kinase associates with a number of proteins including c-Src, Lck, Lyn, Fyn, Vav1, STAT3, SHP1, Grb2, and LAT to couple immunoreceptors to downstream signaling events mediating cellular proliferation, differentiation, and phagocytosis. Syk is modified by phosphorylation on multiple tyrosine sites. Source: Recombinant corresponding to aa359-635 from human SYK, fused to GST-tag at N-terminal, expressed in Sf9 cells. Molecular Weight: ~58kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Specific Activity: ~139pmol/min/ug Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.