C-646, HAT Inhibitor (4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid)

Size

£311.00

SKU:: 136762
Molecular Weight:: 445.4
Purity:: ~98% (TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 328968-36-1
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with sterile dH20.
Extra Details:: Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable. Solubility: DMSO (~10mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.