PAR4 (Proteinase Activated Receptor 4, PAR-4, Coagulation Factor II Receptor-like 3, F2RL3, Thrombin Receptor-like 3)

Size

£685.00

SKU:: 130870
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Partial recombinant corresponding to aa18-83 from F2RL3 (NP_003941) with GST tag. MW of the GST tag alone is 26kD.
Clone:: 5F4
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: Proteinase-Activated Receptor 4 (PAR4) is a member of the Proteinase-Activated Receptor subfamily. Along with other protease-activated receptors, PAR4 mediates the effects of the enzyme, thrombin which include activation of platelets, leukocytes, endothelial cells, and mesenchymal cells at sites of vascular injury. These cellular responses are triggered through proteolytic activation of the receptors by thrombin. It is believed that PAR3 functions as a cofactor for the cleavage and activation of PAR4. PAR4 expression has been documented in the periphery, primarily in blood platelets. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: GGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPA Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.