129526-APC

MDR1 (Multidrug Resistance Protein 1, ABC20, ATP-binding Cassette Sub-family B Member 1, ABCB1, CD243, CLCS, GP170, MGC163296, P-glycoprotein 1, P-GP, PGY1, MGC163296) (APC)

Size

£927.00

SKU:: 129526-APC
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Partial recombinant corresponding to aa620-710 from ABCB1 (NP_000918) with GST tag. MW of the GST tag alone is 26kD.
Clone:: 1F11
Format:: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Extra Details:: The Human multidrug resistance gene MDR1 encodes a membrane-bound protein, referred to as P-glycoprotein that acts as a pump to extrude toxins from cells. The 3' untranslated region (3'UTR) of the Human MDR1 mRNA is very AU-rich (70%). MDR1 is a member of the super family of ATP-binding cassette (ABC) transporters. MDR1 is a member of the MDR/TAP subfamily. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in Human liver, kidney, small intestine and brain. It is localized to Human chromosome 7q21.1. Applications: Suitable for use in FLISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: GIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWP Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Shipping Conditions:: Blue Ice