Kallikrein 11 (KLK11, Hippostasin, hK11, Kallikrein-related Peptidase 11, MGC33060, Protease Serine 20 Trypsin-like, PRSS20, Serine Protease 20, Trypsin-like Serine Protease, TLSP, UNQ649/PRO1279)

Size

£685.00

SKU:: 128710
Application:: WB
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Full length human KLK11, aa1-250 (NP_006844.1).
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK11, also known as hippostatin, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. KLK11 plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLLK11 arefound in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice