127363-APC
GluR1 (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GLUH1, GLURA, GluR-A, GluR-K1, Glutamate Receptor Ionotropic AMPA 1, GluA1, GRIA1, HBGR1, MGC133252) (APC)
Size
£927.00
- SKU:
- 127363-APC
- Application:
- FLISA
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Partial recombinant corresponding to aa151-250 from human GRIA3 (NP_000819) with GST tag. MW of the GST tag alone is 26kD.
- Clone:
- 3D10
- Format:
- Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
- Extra Details:
- Glutamate receptors (GluRs) are the most important mediators of excitatory signal transduction in the central nervous system. They can be pharmacologically classified in three distinct classes: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate (KA) receptors, and N-methyl-D-aspartate (NMDA) receptors. The AMPA-type glutamate receptor opens in response to glutamate binding, and mediates most of the rapid excitatory postsynaptic current. The activation of AMPA receptors leads to stimulation of a multitude of biochemical pathways in postsynaptic neurones eventually leading to postsynaptic neuronal plasticity. GluR1 belongs to the family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. GluR1 gene is located on human chromosome 5q33 and is expressed granule and pyramidal cells in the hippocampal formation. Applications: Suitable for use in FLISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: SLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice