127362-BIOTIN
GluR1 (Glutamate Receptor 1, GluR-1, AMPA-selective Glutamate Receptor 1, GLUH1, GLURA, GluR-A, GluR-K1, Glutamate Receptor Ionotropic AMPA 1, GluA1, GRIA1, HBGR1, MGC133252) (Biotin)
Size
£914.00
- SKU:
- 127362-BIOTIN
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Partial recombinant corresponding to aa201-300 from human GRIA1 (NP_000818) with GST tag. MW of the GST tag alone is 26kD.
- Clone:
- 1G10
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
- Extra Details:
- Glutamate receptors (GluRs) are the most important mediators of excitatory signal transduction in the central nervous system. They can be pharmacologically classified in three distinct classes: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, kainate (KA) receptors, and N-methyl-D-aspartate (NMDA) receptors. The AMPA-type glutamate receptor opens in response to glutamate binding, and mediates most of the rapid excitatory postsynaptic current. The activation of AMPA receptors leads to stimulation of a multitude of biochemical pathways in postsynaptic neurones eventually leading to postsynaptic neuronal plasticity. GluR1 belongs to the family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. GluR1 gene is located on human chromosome 5q33 and is expressed granule and pyramidal cells in the hippocampal formation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: VVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice