058632
TP Receptor (Prostanoid TP Receptor, Thromboxane A2 Receptor, TXA2 Receptor)
Size
£704.00
- SKU:
- 058632
- Application:
- WB
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from an internal region of the mouse TP receptor, aa275-289 (VMSFSGQLLRATEHQ).
- Format:
- Supplied as a liquid from TBS, pH 7.4, 0.1% BSA, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- The TP receptor is a G protein-coupled receptor that mediates the action of thromboxane A2 (TXA2). Alternative splicing of TP pre-mRNA produces two receptor variants, TPα and TPβ, which differ in sequence and the length of their carboxy terminal tail. TP receptors are expressed primarily in platelets but are also expressed in placenta, vascular smooth muscle, brain, small intestine, thymus, kidney, lung, spleen, and monocytes. It signals in a cell type- and expression-dependent manner and has roles in cardiovascular and hemodynamic function Tp-/- mice exhibit coagulation defects, altered vascular responses to TXA2 and arachidonic acid, and increased susceptibility to arachidonic acid-induced shock Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:200 Optimal dilution to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice