IRS1 (Insulin Receptor Substrate 1)

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£453.00

SKU:: 052837
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human IRS1.
Clone:: 25B3 (recomb)
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% BSA, 0.02% sodium azide, 50% glycerol.
Extra Details:: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. Applications: Suitable for use in ELISA, Flow Cytometry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Immunofluorescence: 1:50-1:200 Flow Cytometry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.