052804X

Nav1.7 Na+ Channel (SCN9A, Sodium Channel Nav1.7) (Azide Free)

Size

£812.00

SKU:: 052804X
Purity:: Purified by Protein A affinity chromatography from hybridoma culture.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Fusion protein corresponding to amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7, expressed in E. coli.
Clone:: N68/6
Format:: Supplied as a liquid in PBS. No preservative added. For antibody with azide, see 052804.
Extra Details:: Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. It is expressed at the terminal ends of sensory neurons in the dorsal root ganglion (DRG) and in trigeminal and sympathetic ganglion neurons. A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or “pain receptors” and thus involved in pain sensation. Changes in Nav1.7 expression have been linked to primary erythermalgia, primary erythermalgia, and Congenital insensitivity to pain. Applications: Suitable for use in Immunocytochemistry, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.