Dystrophin (DMD)

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£453.00

SKU:: 052753
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human Dystrophin.
Clone:: 4B10 (recomb)
Format:: Supplied as a liquid in PBS, pH 7.4, 0.05% BSA, 0.02% sodium azide, 50% glycerol.
Extra Details:: DMD is a large cytoskeletal protein that's present on the inside of muscle fibers. DMD, which is found in numerous tissues throughout the body, plays a crucial function in muscle contraction by maintaining the muscle membrane. DMDbinds to a variety of proteins and glycoproteins in skeletal muscle to create the dystrophin-glycoprotein complex (DGC), a key structural unit in skeletal muscle that connects a muscle fiber's cytoskeleton (f-actin) to the extracellular matrix (ECM). DMD deficiency or absence causes two illnesses that result in gradual muscle degeneration. Dystrophin deficiency compromises the sarcolemmal membrane's integrity, making it vulnerable to mechanical damage, leading to Duchenne muscular dystrophy (DMD). Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:200, with antigen retrieval mediated by high pressure in a citrate buffer (pH 6.0) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice