052751
HB9/MNX1 (HB9, Motor Neuron and Pancreas Homeobox Protein 1, HB9, HOXHB9, SCRA1, HLXB9, Homeobox Protein HB9)
Size
£448.00
- SKU:
- 052751
- Purity:
- Purified by affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Chicken/Avian
- Immunogen:
- Recombinant protein encompassing the C-terminal ~150aa of human HB9/MNX1.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
- Extra Details:
- The MNX1/HB9 protein, encoded by the MNX1 gene (also known as HB9), is a transcription factor belonging to the homeobox gene family, which plays an essential role in regulating gene expression during embryonic development. MNX1/HB9 is particularly important in the spinal cord, where it drives the differentiation of motor neurons. Disruptions in MNX1 expression have been associated with developmental disorders and diseases such as spinal muscular atrophy and Currarino syndrome (Han et al 2020). MNX1 also plays a role in certain forms of diabetes, affecting the development of insulin-producing beta cells in the pancreas (Aly et al. 2023). Due to its influence in multiple body systems, understanding MNX1/HB9 function has potential therapeutic implications for both neurodegenerative and metabolic diseases. Applications: Suitable for use in Immunocytochemistry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:200-1:1000 Immunocytochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice