CD41/CD61 (PAC-1 Epitope)

Size

£492.00

SKU:: 052644
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Human platelets
Clone:: PAC-1
Format:: Supplied as a liquid in TBS, pH 8.0, 15mM sodium azide.
Extra Details:: CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120kD transmembrane alpha chain and 23kD extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation. Applications: Suitable for use in Flow Cytometry, Immunocytochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 2-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.