052219
Amyloid Fibrils LOC (Not for Export EU)
Size
£895.00
- SKU:
- 052219
- Purity:
- Serum.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Fibrils prepared from human islet amyloid polypeptide Species Sequence Homology: mouse and rat
- Format:
- Supplied as a liquid, 0.05% sodium azide.
- Extra Details:
- Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. In disease state oligomerization, extensive amyloid oligomerization creates plaques in neural tissue that correlates with Alzheimer’s symptomology. Applications: Suitable for use in ELISA, Western Blot, Dot Blot, Immunoprecipitation, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Dot Blot: 1:1000 detected Amyloid fibrils in fibrils and monomers but not in prefibril oligos. 1:5000, as cited in Glabe C., et al. (2007) Mol Neurodegener 2, 18 shows that the binding with monomers is likely non-specific, and is a possible result of high primary antibody concentration. Optimal dilution determined by the researcher. Control: Alzheimer′s brain tissue Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice