Complement Component 4c, Human

Size

£326.00

SKU:: 052102
Molecular Weight:: 147
Purity:: ≥95% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4.
Extra Details:: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis. Complement C4 (200kD) is composed of three polypeptide chains – α (93kD), β (78kD), and γ (33kD). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9kD) and C4b (190kD). C4b is further cleaved by factor I to C4d (45kD) and C4c (140kD). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified. Protein: 1-5mg/mL (E0.1%280nm = 0.92) Identity: Confirmed by Western Blot Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.