Siglec 10 (Sialic Acid-binding Ig-like Lectin 10, Siglec like Protein 2, SIGLEC10, PRO940, SGL2)

Size

£479.00

SKU:: 048690
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: SIGLEC10 extracellular domain fused with human IgG1 Fc fragment
Clone:: 5G6
Format:: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide
Extra Details:: SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas. Applications: Suitable for use in Flow Cytometry, ELISA and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.