Galectin-3 (Gal-3, 35kD Lectin, Carbohydrate-binding Protein 35, CBP 35, Galactose-specific Lectin 3, Galactoside-binding Protein, GALBP, IgE-binding Protein, L-31, Laminin-binding Protein, Lectin L-29, Mac-2 Antigen, LGALS3, MAC2) (PE)

Size

£685.00

SKU:: 046103
Application:: Flow Cytometry
Purity:: Purified by affinity chromatography
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Partial recombinant protein corresponding to aa151-251 of human Galectin-3. Species sequence homology: African Green, Baboon, Cynomolgus
Clone:: Gal397
Format:: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
Extra Details:: Galectin-3 (galactose-specific lectin 3) is a 30-32kD glycoprotein, also known as Mac-2, Gal-3, RL-29, galactose-specific lectin 3, CBP-35, L-34, and eBP. It is a member of the animal B-galactoside-binding lectin family that is expressed in the cell nucleus, cytoplasm, plasma membrane, or extracellular matrix by variety of tumor cells, monocytes/macrophages, epithelial cells, Kupffer cells, and dendritic cells. Galectin-3 contains carbohydrate recognition domains and binds to B-galactoside residues bearing glycoproteins, such as as IgE, IgA, galactose, casein kinase I, laminin, mucin, LAMPs, and CD66. Galectin-3 is an adhesion molecule and plays an important role in regulation of cell proliferation, differentiation and tumor cell metastasis. Structurally, Galectin-3 possesses NWGR motif that is conserved in the BH-1 domain of the BCL-2 family and functions as an apoptotic molecule. Applications: Suitable for use in Flow Cytometry Other applications not tested. Recommended Dilutions: Flow Cytometry: ≤0.25ug/ml/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Shipping Conditions:: Blue Ice