045929
CD62L (L-Selectin, LSEL, SELL, LAM-1, LECAM1, LEU8, LNHR, LYAM1, PLNHR) (Low Endotoxin/Azide Free)
Size
£512.00
- SKU:
- 045929
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- PMA-activated human peripheral blood leukocytes
- Clone:
- DREG56
- Format:
- Supplied as a liquid in PBS, pH 7.4. No preservative added.
- Extra Details:
- CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). Applications: Suitable for use in Flow Cytometry, Immunoprecipitation, Western Blot, Functional Applications and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 2ug/ml Immunohistochemistry: Frozen Western Blot: Non-reducing conditions. Functional Application: blocking of lymphocyte CD62L-mediated binding to peripheral lymph node HEV. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice