RhoG (ARHG, RHOG Ras Homolog Gene Family, Member G (Rho G))

Size

£709.00

SKU:: 045918
Application:: WB
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: KLH synthetic peptide corresponding to amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180)
Clone:: 1F3 B3 E5
Format:: Supplied as a liquid in PBS, 0.05% sodium azide.
Extra Details:: RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac. Applications: Suitable for use in IWestern Blot. Other applications have not been tested. Recommended Dilution: Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.