045817
HDAC1 (Histone Deacetylase 1) [KO Validated]
Size
£576.00
- SKU:
- 045817
- Purity:
- Purified by affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to the C-terminus of human HDAC1
- Clone:
- 10E2/HDAC1
- Format:
- Supplied as a liquid in PBS
- Extra Details:
- HDAC1 (histone deacetylase 1) is a 65kD member of the Class I histone deacetylase family, which is similar to the yeast RPD3 protein. This nuclear protein operates in concert with histone acetyltransferases to control core histone acetylation in highly conserved lysine residues. HDAC activity has been associated with transcriptional repression and nucleosomal condensation. HDAC1 deacetylates RELA at residue K310, which results in the inhibition of NF-kB activity. HDAC1 has been suggested to participate in the regulation of eukaryotic gene expression and cell cycle progression. HDAC1-deficient mice were shown to be embryonic lethal, suggesting that HDAC1 plays a crucial role during embryonic development. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (paraffin): 10ug/ml Western Blot: 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice