Trichostatin A (TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide)

Size

£298.00

SKU:: 045374
Molecular Weight:: 302.4
Purity:: ≥95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 58880-19-6
Format:: Supplied as an off-white solid.
Extra Details:: Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption. Synonyms: TSA; A300; R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide Source: Isolated from Streptomyces hygroscopicus CAS Number: 58880-19-6 Molecular Formula: C17H22N2O3 Molecular Weight: 302.4 Solubility: DMSO, ethanol, methanol, dimethyl formamide, acetonitrile or chloroform. Insoluble in water or hexane. Appearance: Supplied as an off-white solid. Purity: ≥95% (HPLC) Storage and Stability: Store at -20°C. After reconstitution, prepare aliquots and store at -20°C. Stable for 1 year after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.