TRAIL-R2 (TRAIL Receptor 2, DR5, KILLER, TNFRSF10B, CD262) (Biotin)

Size

£563.00

SKU:: 045356
Purity:: Purified by Protein G affinity chromatography from concentrated hybridoma tissue culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human TRAIL-R2 (DR5).
Clone:: HS201
Format:: Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with Biotin.
Extra Details:: TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Applications: Suitable for use in Immunohistochemistry, Flow Cytometry, Neutralization, Immunocytochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution). Immunohistochemistry (paraffin sections): 15ug/ml Optimal dilutions to be determined by researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice