TRAIL-R1 (TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261)

Size

£576.00

SKU:: 045351
Purity:: Purified by Protein G affinity chromatography from concentrated hybridoma tissue culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human TRAIL-R1 (DR4).
Clone:: HS101
Format:: Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol.
Extra Details:: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Applications: Suitable for use in Flow Cytometry, Neutralization, Immunocytochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.