TRAIL-R1 (TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261) (ATTO 647N)

Size

£576.00

SKU:: 045347
Purity:: Purified by Protein G affinity chromatography from concentrated hybridoma tissue culture supernatant.
Storage Conditions:: 4°C Do Not Freeze
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human TRAIL-R1 (DR4).
Clone:: HS101
Format:: Supplied as a liquid in PBS, 0.02% sodium azide. Labeled with ATTO 647N.
Extra Details:: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Applications: Suitable for use in Flow Cytometry and Immunocytochemistry. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Caution: ATTO 647N conjugates are light sensitive.