SIGIRR, (Human):Fc (Human), Recombinant, (Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule)

Size

£429.00

SKU:: 045281
Molecular Weight:: 50
Purity:: ≥90% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with 100ul sterile ddH2O.
Extra Details:: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Sequence: Signal peptide and extracellular domain of human SIGIRR (aa1-118) are fused at the C-terminus to the Fc portion of human IgG1, expressed in HEK 293 cells. Molecular Weight: ~50kD (SDS-PAGE) Endotoxin: <0.06EU/ug (LAL test; Lonza) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.