(R)-Roscovitine

Size

£247.00

SKU:: 045188
Molecular Weight:: 354.5
Purity:: ≥98% (NMR)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 186692-46-6
Format:: Supplied as a white to off-white solid.
Extra Details:: Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450nM), CDK2 (IC50 = 700nM) and CDK5/p35 (IC50 = 160nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Synonyms: (2R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; (R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; CYC 202; (R)-Roscovitine; R-Roscovitine; Roscovitin; Seliciclib CAS Number: 186692-46-6 Molecular Weight: 354.5 Molecular Formula: C₁₉H₂₆N₆O Solubility: DMSO or 100% ethanol; only moderately soluble in water Appearance: Supplied as a white to off-white solid. Purity: ≥98% (NMR) Storage and Stability: Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.