Progranulin, Recombinant, Mouse (Proepithelin, PEPI, PC Cell-derived Growth Factor)

Size

£479.00

SKU:: 045179
Molecular Weight:: 70
Purity:: ≥95% (SDS-PAGE). Endotoxin: <0.01EU/ug (LAL test; Lonza).
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder PBS. Reconstitute with sterile ddH2O to 0.1mg/ml.
Extra Details:: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Sequence: Signal peptide and mouse progranulin (aa1-589) is untagged. Reflects the native sequence with no additional aa. Molecular Weight: ~70kD (SDS-PAGE) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice