Progranulin, Recombinant, Human, aa1-593 (Proepithelin, PEPI, PC Cell-derived Growth Factor)

Size

£416.00

SKU:: 045177
Molecular Weight:: 74
Purity:: ≥98% (SDS-PAGE). Endotoxin: <0.01EU/ug (LAL test; Lonza)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in PBS. Reconstitute with sterile ddH2O.
Extra Details:: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Sequence: Signal peptide and human progranulin (aa1-593) is untagged. Reflects the native sequence with no additional aa. Biological Activity: Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight. Molecular Weight: ~74kD (glycosylated protein by SDS-PAGE) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice