Phorbol 12-myristate 13-acetate 98+% (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate)

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£283.00

SKU:: 045147
Molecular Weight:: 616.83
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 16561-29-8
Extra Details:: Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Synonyms: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate CAS Number: 16561-29-8 Molecular Formula: C36H56O8 Molecular Weight: 616.83 Purity: ≥98% (HPLC) Appearance: White to off-white solid Solubility: Soluble in DMSO (20mg/ml) 100% ethanol (20mg/ml), methanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers. Method for Determining Identity: 1H-NMR Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.