LAG-3 (blocking) (Lymphocyte Activation Gene-3, FDC Protein, CD223)

Size

£557.00

SKU:: 044991
Purity:: ≥95% (SDS-PAGE). Endotoxin: ≤1EU/mg (LAL).
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Synthetic peptide corresponding to 30aa in the N-terminus of human LAG-3.
Clone:: 17B4
Format:: Supplied as a liquid in PBS. No preservative added.
Extra Details:: Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. Applications: Suitable for use in Immunocytochemistry, Flow Cytometry, Western Blot, Immunohistochemistry, Immunoprecipitation and Inhibiton. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen): 1:150 Immunoprecipitation: 10ug/ml Western Blot: 5ug/ml Optimal dilutions to be determined by researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.