Jagged-1, Recombinant, Mouse,Fc Human (Protein Jagged-1, CD339, JAG1)

Size

£409.00

SKU:: 044969
Molecular Weight:: 150
Purity:: ≥90% (SDS-PAGE). Endotoxin: ≤0.01EUug (LAL)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF). Biological Activity: Inhibits adipogenesis of 3T3L-1 cells Sequence: Signal peptide and extracellular domain of mouse Jagged-1 (aa1-1067) are fused at the C-terminus to the Fc portion of human IgG. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.